Risk Assessment of the Insecticide Plenum 50 WG with the Active Substances Pymetrozine

Plenum is a new insecticide containing the active substance pymetrozine. an against different pests in ornamentals, lettuce, cucumber and tomato greenhouse pollen beetles oilseed- turnip rapes. The risk assessment was finalized at meeting Mai 29, 2012, by VKM’s Scientific Panel on plant protection products (VKM). particular asked Norwegian Food Safety Authority to look following: 
 human health for operators related properties of product. o effects seen studies dog if these warrant classification chronic toxicity. oncogenic liver lungs genotoxicity metabolite CGA 300407. reproduction teratology developmental neurotoxicity study toxicity establishment NOAELs reference values (ADI, AOEL ARfD). labelling substances product.
 conclusion as follows: reported repeated dose with dogs should be considered adverse. increased incidence lung tumors relevant humans. It cannot excluded that genotoxic mechanism could involved formation tumors, which would have implications assessment. therefore test pymetrozine more sensitive vivo endpoints liver. teratogenicity rats rabbits Risk calculations both German model UK POEM show low personal equipment used.
 VKM propose:
 NOAEL 0.6 mg/kg bw/day based 1-year dogs.
 0.006 value from one year UF 100.
 ADI ARfD 0.02 LOAEL 8.1 500 (10 x interspecies difference, 10 intraspecies 3 due use 2 adversity neurodevelopmental effects).
 supports proposal Authority.